Difference Between Lock And Key Model And Induced Fit Model Of Enzyme Action

There is no change in shape of the active site.

Difference between lock and key model and induced fit model of enzyme action.

Induced fit and lock and key are the two models which describe the mechanism of action of the enzyme. Daniel e koshland formulated this hypothesis in 1959. Enzymes have very precise shape which includes a cleft or pocket called active sites. The key difference between induced fit and lock and key is that in induced fit theory the binding of the substrate with the active site of the enzyme induces the modification of the shape of the active site into the complementary shape of the substrate.

The lock and key model suggests that the substrate is completely complementary in shape to the active site so that it fits in perfectly i e. In this theory the substrate fits into an active site like a key into a lock. The lock and key model and the induced fit hypothesis are two potential models for how substrates may bind in the active site of an enzyme. The way a key the substrate fits into a lock the enzyme.

Instead the substrate interacts with the active site and both change their shape to fit together. Whereas in the lock and key theory the substrate and the active site of the enzyme are complementary in shape at the beginning. Two main theories are used to explain how enzyme substrate complexes form. They are important in describing how enzymes increase the rate of a biological reaction through catalysis.

According to this hypothesis the active site does not have a rigid lock and key conformation. The induced fit model is an elaboration on the basic idea of the lock and key model. They are lock and key theory and induced fit theory. Both models depend on the degree of precise binding of the substrate to the active site of the enzyme.